Researchers from Hyderabad, city-based CSIR-Centre for Cellular and Molecular Biology and other institutes have for the first time identified that an X chromosome gene (TEX13B) is essential for sperm cell development and male fertility.
Nearly one in seven couples worldwide is infertile, CSIR-Centre for Cellular and Molecular Biology (CCMB) said on Thursday.
Male factors account for 50 percent of total infertility due to abnormal semen parameters, such as low sperm count, abnormal sperm motility, abnormal sperm shape and size.
An important factor behind these reasons is genetic factors.
In a new multi-institutional study, scientists from the CSIR-Centre for Cellular and Molecular Biology "identified for the first time that the gene TEX13B is essential for sperm cell development and male fertility", a CCMB release said.This study has recently been published in the Journal of Human Reproduction.
"Using next-generation sequencing, we compared all the gene coding regions (exons) between infertile and fertile men. We found two causative mutations in the TEX13B gene, one of which was found exclusively in infertile men and The second is found more frequently in infertile men than in fertile men,” said first author Umesh Kumar, a PhD student at CCMB.
Researchers have developed a cell culture model of rat sperm-producing cells by deleting the Tex13b gene using 'CRISPR-Cas9' technology.They found that destruction of the TEX13B gene reduces the respiratory capacity of Th cells. They also found that Tex13b regulates energy metabolism in sperm-producing cells. Together, they argue that this affects the formation of new sperm cells, the release said.
"The findings of this study will be useful for screening infertile men with spermatogenic failure and counseling them before implementation of assisted reproductive technology," said Vinay Kumar Nandikoori, director of CCMB.
The release said the study is a reminder of how genetic trait transmission can be more complex, and more subtle, than has been superficially thought.“TEX13B is present on the But when the ."
Nearly one in seven couples worldwide is infertile, CSIR-Centre for Cellular and Molecular Biology (CCMB) said on Thursday.
Male factors account for 50 percent of total infertility due to abnormal semen parameters, such as low sperm count, abnormal sperm motility, abnormal sperm shape and size.
An important factor behind these reasons is genetic factors.
In a new multi-institutional study, scientists from the CSIR-Centre for Cellular and Molecular Biology "identified for the first time that the gene TEX13B is essential for sperm cell development and male fertility", a CCMB release said.This study has recently been published in the Journal of Human Reproduction.
"Using next-generation sequencing, we compared all the gene coding regions (exons) between infertile and fertile men. We found two causative mutations in the TEX13B gene, one of which was found exclusively in infertile men and The second is found more frequently in infertile men than in fertile men,” said first author Umesh Kumar, a PhD student at CCMB.
Researchers have developed a cell culture model of rat sperm-producing cells by deleting the Tex13b gene using 'CRISPR-Cas9' technology.They found that destruction of the TEX13B gene reduces the respiratory capacity of Th cells. They also found that Tex13b regulates energy metabolism in sperm-producing cells. Together, they argue that this affects the formation of new sperm cells, the release said.
"The findings of this study will be useful for screening infertile men with spermatogenic failure and counseling them before implementation of assisted reproductive technology," said Vinay Kumar Nandikoori, director of CCMB.
The release said the study is a reminder of how genetic trait transmission can be more complex, and more subtle, than has been superficially thought.“TEX13B is present on the But when the ."
