New Delhi: According to new research, an abnormal form of cell death can cause extreme damage to the lungs of a Covid patient, resulting in potentially life-threatening conditions such as inflammation and acute respiratory disorders.
The study suggests that the ability to prevent this unusual form of cell death – ferroptosis – offers doctors new ways to treat COVID-19 lung disease.
Cell death, where a cell stops functioning, can be natural or caused by causes such as disease or injury.
The most common form of cell death is cells "cutting off" the molecules inside, the researchers said, which also happens in humans when they are sick or old.
However, researchers at Columbia University US said, in ferroptosis, a relatively uncommon form of cell death, cells die as their outer fat layers collapse.In this study, they analyzed human tissues and collected autopsies from patients who died of respiratory failure due to COVID. -19 infection. Hamster samples were also analyzed.
The team found that most of the cells were dying through the ferroptosis mechanism that causes lung disease in Covid patients.
Therefore, drugs that target and prevent the ferroptosis form of cell death may help improve the treatment course of COVID-19, the researchers said.
Brent Stockwell, chair of the department of biological sciences at Columbia, said, “This discovery adds important insights to our understanding of how COVID-19 affects the body, thereby improving our ability to fight life-threatening cases of the disease.” There will be a lot of improvement." -lead author of the study published in the journal Nature Communications.
Previous studies have shown that ferroptosis, while helpful in some normal physiological processes, can also attack and kill healthy cells in patients with neurodegenerative diseases such as Parkinson's and Alzheimer's disease.
The authors said the ability to inhibit ferroptosis could provide doctors with new ways to deal with cell death that shouldn't occur, as is the case with COVID-19 lung disease.
Stockwell said, "We hope that these important new findings can improve our ability to combat this dangerous disease which, in many cases, still has adverse health effects and causes death."
The study suggests that the ability to prevent this unusual form of cell death – ferroptosis – offers doctors new ways to treat COVID-19 lung disease.
Cell death, where a cell stops functioning, can be natural or caused by causes such as disease or injury.
The most common form of cell death is cells "cutting off" the molecules inside, the researchers said, which also happens in humans when they are sick or old.
However, researchers at Columbia University US said, in ferroptosis, a relatively uncommon form of cell death, cells die as their outer fat layers collapse.In this study, they analyzed human tissues and collected autopsies from patients who died of respiratory failure due to COVID. -19 infection. Hamster samples were also analyzed.
The team found that most of the cells were dying through the ferroptosis mechanism that causes lung disease in Covid patients.
Therefore, drugs that target and prevent the ferroptosis form of cell death may help improve the treatment course of COVID-19, the researchers said.
Brent Stockwell, chair of the department of biological sciences at Columbia, said, “This discovery adds important insights to our understanding of how COVID-19 affects the body, thereby improving our ability to fight life-threatening cases of the disease.” There will be a lot of improvement." -lead author of the study published in the journal Nature Communications.
Previous studies have shown that ferroptosis, while helpful in some normal physiological processes, can also attack and kill healthy cells in patients with neurodegenerative diseases such as Parkinson's and Alzheimer's disease.
The authors said the ability to inhibit ferroptosis could provide doctors with new ways to deal with cell death that shouldn't occur, as is the case with COVID-19 lung disease.
Stockwell said, "We hope that these important new findings can improve our ability to combat this dangerous disease which, in many cases, still has adverse health effects and causes death."
