The study, based on data from more than 1 million individuals and published in the journal Nature Genetics, shows that blood pressure is a highly heritable trait influenced by thousands of different genetic variants.
"We have now uncovered a much larger proportion of the genetic contribution to blood pressure than previously thought," said Helen Warren, senior lecturer in statistical genetics at Queen Mary University of London.
“We are making our polygenic risk score data publicly available. The genetic risk score has a variety of potential applications, so it will be exciting to see how our blood pressure score can be used to address more clinically relevant questions in the future.” How can it be used." Added.
For the study, the team combined four large datasets from genome-wide association studies (GWAS) of blood pressure and hypertension.
The researchers said additional genomic locations also explain a large portion of the genetic variation in people's levels of high blood pressure.
The findings may yield potential new drug targets, and help advance precision medicine in the early detection and prevention of high blood pressure (hypertension).
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"We have now uncovered a much larger proportion of the genetic contribution to blood pressure than previously thought," said Helen Warren, senior lecturer in statistical genetics at Queen Mary University of London.
“We are making our polygenic risk score data publicly available. The genetic risk score has a variety of potential applications, so it will be exciting to see how our blood pressure score can be used to address more clinically relevant questions in the future.” How can it be used." Added.
For the study, the team combined four large datasets from genome-wide association studies (GWAS) of blood pressure and hypertension.
The researchers said additional genomic locations also explain a large portion of the genetic variation in people's levels of high blood pressure.
The findings may yield potential new drug targets, and help advance precision medicine in the early detection and prevention of high blood pressure (hypertension).
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