According to the study published in the New England Journal of Medicine, researchers identified 'anti-nephrin autoantibodies' as a reliable biomarker to monitor disease progression, opening new avenues for personalized treatment approaches.
Nephrotic syndrome, characterized by high protein levels in the urine, is associated with kidney diseases such as minimal change disease (MCD), primary focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN).
According to researchers, the primary reason behind this syndrome is damage to T podocytes, which are the cells responsible for filtering the kidneys, which allows proteins to leak into the urine.
To diagnose such conditions, researchers introduced a new technique combining immunoprecipitation with enzyme-linked immunosorbent assay (ELISA) to reliably detect anti-nephrin autoantibodies.
Co-author Dr. Nicola M. Tomas said, “The identification of anti-nephrin autoantibodies as a reliable biomarker, combined with our hybrid immunoprecipitation technique, advances our clinical practice in kidney disorders with nephrotic syndrome and disease progression.” "Will advance capabilities to a great extent." "New avenues for close surveillance."
The findings showed that anti-nephrin autoantibodies were prevalent in 69 percent of adults with MCD and 90 percent of children with INS (idiopathic nephrotic syndrome) who were not treated with immunosuppressive drugs.
"Importantly, levels of these autoantibodies correlate with disease activity, suggesting their potential as biomarkers to monitor disease progression," the researchers said. Very few antibodies were seen in other diseases also. Was."
Nephrotic syndrome, characterized by high protein levels in the urine, is associated with kidney diseases such as minimal change disease (MCD), primary focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN).
According to researchers, the primary reason behind this syndrome is damage to T podocytes, which are the cells responsible for filtering the kidneys, which allows proteins to leak into the urine.
To diagnose such conditions, researchers introduced a new technique combining immunoprecipitation with enzyme-linked immunosorbent assay (ELISA) to reliably detect anti-nephrin autoantibodies.
Co-author Dr. Nicola M. Tomas said, “The identification of anti-nephrin autoantibodies as a reliable biomarker, combined with our hybrid immunoprecipitation technique, advances our clinical practice in kidney disorders with nephrotic syndrome and disease progression.” "Will advance capabilities to a great extent." "New avenues for close surveillance."
The findings showed that anti-nephrin autoantibodies were prevalent in 69 percent of adults with MCD and 90 percent of children with INS (idiopathic nephrotic syndrome) who were not treated with immunosuppressive drugs.
"Importantly, levels of these autoantibodies correlate with disease activity, suggesting their potential as biomarkers to monitor disease progression," the researchers said. Very few antibodies were seen in other diseases also. Was."
