Current guidelines call for increasing dietary intake of unsaturated fats while reducing saturated fats to prevent cardiometabolic diseases, including heart attack, stroke, diabetes, and insulin resistance.

The new study published in Nature Medicine shows that controlled dietary replacement of saturated fat with unsaturated fat may be good for health and reduce cardiometabolic risk.

For the study, the team included 113 participants, who were divided into two groups: one group had a diet rich in saturated animal fats, while the other group had a diet rich in unsaturated plant-based fats.

They were followed for 16 weeks, and their blood samples were analyzed using lipidomics, or the analysis of fats in the blood.

A high multi-lipid score (MLS). A healthy fat-rich diet was found to be linked to 32 percent lower incidence of heart disease and 26 percent lower incidence of type 2 diabetes.

"The study confirms with greater certainty the health benefits of a diet high in unsaturated vegetable fats such as the Mediterranean diet and may help to provide targeted dietary advice to those who would benefit most from changing their eating habits", the research said Chief Clemens Wittenbecher. At Chalmers University of Technology in Sweden.

The study also showed that it is possible to accurately measure diet-related fat changes in the blood and that they can be directly linked to the risk of developing heart disease and type 2 diabetes. It also highlighted the potential of lipidomics-based scores to target and monitor dietary interventions in a biomarker-guided precision nutrition approach.