Tuberculosis is the second leading infectious disease killer globally with over 2.95 million active cases in 2020 in India alone. Of these, 135,000 were classified as multidrug-resistant TB cases.
Dr. D.Y. The study by IIT-Bombay startup HaystackAnalytics in collaboration with. Patil Medical College, Pune, India based on data from 600 patients with drug-resistant TB.
Data collected using the WGS method revealed that pre-extensively drug-resistant TB (pre-XDR-TB) was present in 50.83 per cent of cases, while multidrug-resistant TB (MDR-TB) was found in 15.5 per cent of cases. Was.Equal ratio between men and women.
These patients were not only resistant to rifampicin
--, and isoniazid
-Line treatment of active Mycobacterium tuberculosis (TB infection), but also fluoroquinolones
, the researchers said.
“I believe that, going forward, whole-genome sequencing could become the first of many tests that will be prescribed for all TB patients not just in India but across the world,” Dr. Anirvan Chatterjee, CEO and co-founder HaystackAnalytics told IANS.
“WGS is the new gold standard for TB diagnosis and is the way forward for the world to eliminate TB cases,” he said.
Additionally, the study revealed that 55 percent of people between the ages of 15-35 and 67 percent of people up to the age of 14 had pre-XDR TB."Actually young people are getting tuberculosis, which is a cause for concern because this is a productive age group and TB is extremely harmful to the young population," Anirvan said.
“In fact, there is a lot of drug resistance in the younger age group, which is of great concern for productivity reasons,” he said, noting that it also increases the risk of active transmission of drug-resistant TB. .
They reported that "WGS can detect drug resistance to 18 antibiotics in a single test", eliminating the need for multiple tests.
“If it is available or is sought when early symptoms of tuberculosis appear, the treatment will be of short duration. This will also improve the results. If a person is given the right antibiotic, transmission is reduced by more than 9 percent, meaning we will be able to reduce new TB cases.And that is me, the holy grail,” the doctor told IANS.
Dr. D.Y. The study by IIT-Bombay startup HaystackAnalytics in collaboration with. Patil Medical College, Pune, India based on data from 600 patients with drug-resistant TB.
Data collected using the WGS method revealed that pre-extensively drug-resistant TB (pre-XDR-TB) was present in 50.83 per cent of cases, while multidrug-resistant TB (MDR-TB) was found in 15.5 per cent of cases. Was.Equal ratio between men and women.
These patients were not only resistant to rifampicin
--, and isoniazid
-Line treatment of active Mycobacterium tuberculosis (TB infection), but also fluoroquinolones
, the researchers said.
“I believe that, going forward, whole-genome sequencing could become the first of many tests that will be prescribed for all TB patients not just in India but across the world,” Dr. Anirvan Chatterjee, CEO and co-founder HaystackAnalytics told IANS.
“WGS is the new gold standard for TB diagnosis and is the way forward for the world to eliminate TB cases,” he said.
Additionally, the study revealed that 55 percent of people between the ages of 15-35 and 67 percent of people up to the age of 14 had pre-XDR TB."Actually young people are getting tuberculosis, which is a cause for concern because this is a productive age group and TB is extremely harmful to the young population," Anirvan said.
“In fact, there is a lot of drug resistance in the younger age group, which is of great concern for productivity reasons,” he said, noting that it also increases the risk of active transmission of drug-resistant TB. .
They reported that "WGS can detect drug resistance to 18 antibiotics in a single test", eliminating the need for multiple tests.
“If it is available or is sought when early symptoms of tuberculosis appear, the treatment will be of short duration. This will also improve the results. If a person is given the right antibiotic, transmission is reduced by more than 9 percent, meaning we will be able to reduce new TB cases.And that is me, the holy grail,” the doctor told IANS.
