Patil followed his father's footsteps and started his career as a police constable in Gujarat in 1975.

He served in this position for 14 years before being transferred to other areas.

Before joining politics, Patil used to work in journalism. He joined the Gujarati daily 'Navgujarat Times' in 1991, which enhanced his understanding of media and public communication.

He started his political journey with BJP in 1989 and has since held many important positions within the party.Patil's roles include treasurer and later vice president of the BJP Surat city unit. His dedication and effectiveness in these roles earned him the chairmanship of Gujarat Alkalies and Chemicals Limited, a state public sector undertaking.

Patil was first elected to Parliament from the Navsari constituency in 2009, retaining the seat in subsequent elections.

His tenure in Parliament is distinguished by active participation in several key committees, including Urban Development, Health and Family Welfare and Civil Aviation.

As an MP, Patil has played a key role in several development projects in his home constituency and the state.Notably, he was instrumental in upgrading the Surat Airport, turning it into a hub serving many national and international flights.

He has also been involved in promoting textile, infrastructure and diamond industries in Surat.

Under his initiative, Navsari became India's first "smoke-free" district, with zero use of firewood or kerosene, thereby promoting the use of clean energy sources.

Patil's electoral success is notable for the large margin by which he won.

In the 2014 and 2019 Lok Sabha elections, he achieved some of the highest vote margins recorded in the country.In 2013, he became the first Indian MP to receive ISO certification for quality management system in monitoring and administration of government services for his constituency.

Eventually, in 2020, Patil was appointed as the president of the Gujarat state unit of the BJP, becoming the first non-Gujarati to hold the post.