According to Dr Meet Kumar, Clinical Director, Hematology and Bone Marrow Transplant, Marengo Asia Hospital, Gurugram, gene editing has been tested as a potential treatment method for sickle cell disease in clinical trials.
According to preliminary findings, normal hemoglobin production can be enabled, which could significantly reduce the symptoms and effects of sickle cell disease.
According to experts, in sickle cell disease, blood can become too thick and form clots, leading to various brain problems such as silent stroke, regular stroke (both where blood flow is blocked and where bleeding occurs), and other problems. May be born. This happens because thickened blood can block blood vessels in the brain.
“About 40 percent of children under age 18 have silent cerebral infarcts.About 36 percent of children with sickle cell anemia have headaches. Ischemic stroke occurs in about 10 percent of children, and hemorrhagic stroke occurs at a higher rate in children. "About 3-10 per cent," Dr Praveen Gupta, principal director and head of neurology, Fortis Hospital, told IANS.
Experts said sickle cell disease can affect the brain in a variety of ways, including cognitive impairments such as working memory, verbal learning, visual motor function, inadequacies in general intellectual functioning, problems with language and attention, as well as headaches, seizures and Others are included. ,
Dr. Gaurav Kharya, Founder and Director of Cellogen Therapeutics, said that gene therapy represents one of the most promising advances in the treatment of sickle cell disease.This approach involves modifying the patient's own hematopoietic stem cells to correct the genetic defect responsible for the disease. He further noted that the modified stem cells are "then reintroduced into the patient's body".
“Early clinical trials have shown promising results, with significant improvements in symptoms and quality of life in some patients,” Kharya said."
According to preliminary findings, normal hemoglobin production can be enabled, which could significantly reduce the symptoms and effects of sickle cell disease.
According to experts, in sickle cell disease, blood can become too thick and form clots, leading to various brain problems such as silent stroke, regular stroke (both where blood flow is blocked and where bleeding occurs), and other problems. May be born. This happens because thickened blood can block blood vessels in the brain.
“About 40 percent of children under age 18 have silent cerebral infarcts.About 36 percent of children with sickle cell anemia have headaches. Ischemic stroke occurs in about 10 percent of children, and hemorrhagic stroke occurs at a higher rate in children. "About 3-10 per cent," Dr Praveen Gupta, principal director and head of neurology, Fortis Hospital, told IANS.
Experts said sickle cell disease can affect the brain in a variety of ways, including cognitive impairments such as working memory, verbal learning, visual motor function, inadequacies in general intellectual functioning, problems with language and attention, as well as headaches, seizures and Others are included. ,
Dr. Gaurav Kharya, Founder and Director of Cellogen Therapeutics, said that gene therapy represents one of the most promising advances in the treatment of sickle cell disease.This approach involves modifying the patient's own hematopoietic stem cells to correct the genetic defect responsible for the disease. He further noted that the modified stem cells are "then reintroduced into the patient's body".
“Early clinical trials have shown promising results, with significant improvements in symptoms and quality of life in some patients,” Kharya said."
