To date, researchers have not developed fully functional human immune systems, but only those with a brief lifespan that do not develop efficient immune responses, allowing them to develop in vivo human immunotherapy, human disease modeling, or human vaccine development. Become unsuitable.
Developed by scientists at the University of Texas in the US, the new model will overcome the limitations of currently available in vivo human models and is a breakthrough for biomedical research and promises new insights into immunotherapy development and disease modeling.
As detailed in the journal Nature Immunology, the new humanized mice, called TruHUX (actually human or THX), have a fully developed and fully functional human immune system, including lymph nodes, germinal center, thymus, Human epithelial cells, include human T and B. Lymphocytes, memory B lymphocytes and plasma cells produce highly specific antibodies and autoantibodies, similar to those in humans.
THX mice develop mature neutralizing antibody responses to Salmonella Typhimurium and SARS-CoV-2 virus Spike S1 RBD after vaccination with Salmonella flagellin and Pfizer COVID-19 mRNA vaccine, respectively.
It is also capable of developing full-blown systemic lupus autoimmunity after injection of Pristane.
"THX mice provide a platform for the study of the human immune system, the development of human vaccines, and clinical trials," said Professor Paolo Casali of the University of Texas School of Medicine at San Antonio, US.
"They do this by critically taking advantage of estrogen activity to support human stem cell and human immune cell differentiation and antibody responses," he said.
Developed by scientists at the University of Texas in the US, the new model will overcome the limitations of currently available in vivo human models and is a breakthrough for biomedical research and promises new insights into immunotherapy development and disease modeling.
As detailed in the journal Nature Immunology, the new humanized mice, called TruHUX (actually human or THX), have a fully developed and fully functional human immune system, including lymph nodes, germinal center, thymus, Human epithelial cells, include human T and B. Lymphocytes, memory B lymphocytes and plasma cells produce highly specific antibodies and autoantibodies, similar to those in humans.
THX mice develop mature neutralizing antibody responses to Salmonella Typhimurium and SARS-CoV-2 virus Spike S1 RBD after vaccination with Salmonella flagellin and Pfizer COVID-19 mRNA vaccine, respectively.
It is also capable of developing full-blown systemic lupus autoimmunity after injection of Pristane.
"THX mice provide a platform for the study of the human immune system, the development of human vaccines, and clinical trials," said Professor Paolo Casali of the University of Texas School of Medicine at San Antonio, US.
"They do this by critically taking advantage of estrogen activity to support human stem cell and human immune cell differentiation and antibody responses," he said.
