Both midfielders will not travel to Germany after being selected in Gareth Southgate's provisional 33-man squad, the Daily Mail reports.
The final 26-man squad will be announced on Saturday after a friendly against Iceland at Wembley Stadium in London.
Following Maddison's departure from training camp, expectations have increased for Eberechi Eze and Jarrod Bowen to be included in the final squad.
Additionally, Liverpool defender Jerrel Kwansa is also expected to be left out of the squad following his first call-up, the report adds.
England will also be boosted by Luke Shaw's health update as he speeds up his recovery from a hamstring injury. The Manchester United defender has not played a match in the last three months but was selected in England's extended squad.
Nevertheless, given his injury history and prolonged inactivity, there are still questions about his availability for competition.
However, Shaw has made huge strides in demonstrating his fitness even before Southgate announces his final 26-man roster for the competition on Saturday.
The final 26-man squad will be announced on Saturday after a friendly against Iceland at Wembley Stadium in London.
Following Maddison's departure from training camp, expectations have increased for Eberechi Eze and Jarrod Bowen to be included in the final squad.
Additionally, Liverpool defender Jerrel Kwansa is also expected to be left out of the squad following his first call-up, the report adds.
England will also be boosted by Luke Shaw's health update as he speeds up his recovery from a hamstring injury. The Manchester United defender has not played a match in the last three months but was selected in England's extended squad.
Nevertheless, given his injury history and prolonged inactivity, there are still questions about his availability for competition.
However, Shaw has made huge strides in demonstrating his fitness even before Southgate announces his final 26-man roster for the competition on Saturday.
