New Delhi: According to a new research, more than 2,000 regions on the human genome have been found to affect a person's blood pressure and, as a result, make them more prone to developing high blood pressure.
Genomics is the study of an individual's entire genetic makeup, including the interrelationships between genes, which are the segments that make up the DNA that reside inside human cells.
Data from more than one million people were analyzed to discover regions on the genome, including more than 100 new regions associated with blood pressure. The international study led by Queen Mary University of London, UK, has been published in the journal Nature Genetics.
"Our study found additional genomic loci that explain a large portion of the genetic variation in people's blood pressure.Knowing a person's risk for developing high blood pressure can lead to tailored treatments that are more likely to be effective," said first author Jacob Keaton, staff scientist at the U.S. National Human Genome Research Institute (NHGRI).
Several newly discovered genome locations were found within genes important for iron metabolism.
The researchers said this result confirmed previous findings that high levels of accumulated iron may contribute to the development of heart disease.
It is known that high blood pressure runs in families, which points to heredity. This means there is a genetic component involved in developing the condition, in addition to environmental conditions, such as high-salt dietary intake, low exercise, smoking and stress, the team explained.Persistent high blood pressure can damage the heart and blood vessels, increasing a person's risk of heart disease, stroke and other conditions.
As part of their analysis, the researchers calculated a polygenic risk score to predict a person's blood pressure and risk of hypertension. The score I arrived at is by considering all the genomic variants in a person that confer risk for hypertension.
The team said the scores revealed clinically meaningful differences between people's blood pressure.
“We are making our polygenic risk score data publicly available.The genetic risk score has a variety of potential applications, so it will be exciting to see how our blood pressure score can be used to address more clinically relevant questions in the future." Statistical Genetics at Queen Mary University of London said author Helen Warren, senior lecturer at the
Patricia Munro, professor of molecular medicine at Queen Mary University of London, said: "Our results provide new resources for understanding biological mechanisms, including new polygenic risk scores important for early identification and stratification of people at risk of cardiovascular disease. provide."
"This large study builds on more than 18 years of blood pressure GWAS research. A GWAS – genome-wide association study – is a research approach that uses data to identify genomic variants associated with the risk of a disease," said senior author Munro. Uses.,
In this study, data came from four datasets of GWAS of blood pressure and hypertension, including the UK Biobank and the International Consortium for Blood Pressure.
Genomics is the study of an individual's entire genetic makeup, including the interrelationships between genes, which are the segments that make up the DNA that reside inside human cells.
Data from more than one million people were analyzed to discover regions on the genome, including more than 100 new regions associated with blood pressure. The international study led by Queen Mary University of London, UK, has been published in the journal Nature Genetics.
"Our study found additional genomic loci that explain a large portion of the genetic variation in people's blood pressure.Knowing a person's risk for developing high blood pressure can lead to tailored treatments that are more likely to be effective," said first author Jacob Keaton, staff scientist at the U.S. National Human Genome Research Institute (NHGRI).
Several newly discovered genome locations were found within genes important for iron metabolism.
The researchers said this result confirmed previous findings that high levels of accumulated iron may contribute to the development of heart disease.
It is known that high blood pressure runs in families, which points to heredity. This means there is a genetic component involved in developing the condition, in addition to environmental conditions, such as high-salt dietary intake, low exercise, smoking and stress, the team explained.Persistent high blood pressure can damage the heart and blood vessels, increasing a person's risk of heart disease, stroke and other conditions.
As part of their analysis, the researchers calculated a polygenic risk score to predict a person's blood pressure and risk of hypertension. The score I arrived at is by considering all the genomic variants in a person that confer risk for hypertension.
The team said the scores revealed clinically meaningful differences between people's blood pressure.
“We are making our polygenic risk score data publicly available.The genetic risk score has a variety of potential applications, so it will be exciting to see how our blood pressure score can be used to address more clinically relevant questions in the future." Statistical Genetics at Queen Mary University of London said author Helen Warren, senior lecturer at the
Patricia Munro, professor of molecular medicine at Queen Mary University of London, said: "Our results provide new resources for understanding biological mechanisms, including new polygenic risk scores important for early identification and stratification of people at risk of cardiovascular disease. provide."
"This large study builds on more than 18 years of blood pressure GWAS research. A GWAS – genome-wide association study – is a research approach that uses data to identify genomic variants associated with the risk of a disease," said senior author Munro. Uses.,
In this study, data came from four datasets of GWAS of blood pressure and hypertension, including the UK Biobank and the International Consortium for Blood Pressure.
