Without enough insulin, diabetics may be at risk for hyperglycemia, or high blood sugar, which can damage blood vessels and organs as well as lead to heart attacks, strokes and other serious complications.
The study published in the journal Nature Communications suggests that Fok adhesion kinase (FAK) inhibitors, known to reduce tumor burden in pancreatic cancer, may be a new opportunity as a replacement for insulin therapy in patients with diabetes. . , Are.
In an experiment on mice that began in 2016, the University of Pittsburgh team deleted one of two copies of the gene that encodes an enzyme called protein adhesion kinase (FAK).
Both the pancreas and the group of cells in the organ looked strange. While the pancreas "looked as if it was trying to regenerate after an injury", the cells were "expressing both insulin and amylase".
The group of cells looked like a combination of acinar cells
, a digestive enzyme, and beta-cells
- Controlling hormone insulin.
"There were three possible explanations for what we saw in the mutant mice," Esni said. “It could just be the result of our experiment, the beta cells could start making amylase or the acinar cells could start producing insulin.
,
The team further showed that "the FAK-inhibiting drug, which has been studied in cancer treatment, transformed acinar cells into acinar-derived insulin-producing (ADIP) cells and reduced blood pressure in diabetic mice and a non-human primate." done." "To control glucose".
The study published in the journal Nature Communications suggests that Fok adhesion kinase (FAK) inhibitors, known to reduce tumor burden in pancreatic cancer, may be a new opportunity as a replacement for insulin therapy in patients with diabetes. . , Are.
In an experiment on mice that began in 2016, the University of Pittsburgh team deleted one of two copies of the gene that encodes an enzyme called protein adhesion kinase (FAK).
Both the pancreas and the group of cells in the organ looked strange. While the pancreas "looked as if it was trying to regenerate after an injury", the cells were "expressing both insulin and amylase".
The group of cells looked like a combination of acinar cells
, a digestive enzyme, and beta-cells
- Controlling hormone insulin.
"There were three possible explanations for what we saw in the mutant mice," Esni said. “It could just be the result of our experiment, the beta cells could start making amylase or the acinar cells could start producing insulin.
,
The team further showed that "the FAK-inhibiting drug, which has been studied in cancer treatment, transformed acinar cells into acinar-derived insulin-producing (ADIP) cells and reduced blood pressure in diabetic mice and a non-human primate." done." "To control glucose".
